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Antigen Agriculture Technology (AST) is a Potent and Complimentary Accession to Company’s Engineered Adulteration Bodies (ETB) Technology



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AUSTIN, Texas, Nov. 09, 2018 (GLOBE NEWSWIRE) — Molecular Templates, Inc., (Nasdaq: MTEM), a clinical-stage oncology aggregation focused on the analysis and development of the company’s proprietary engineered adulteration bodies (ETBs), which are differentiated, targeted, biologic analysis for cancer, appear the presentation today of a affiche on its PD-L1 ETB with Antigen Agriculture Technology (AST) at the ongoing Society for Immunotherapy of Cancer’s (SITC) 33rd Annual Meeting, currently demography abode in Washington D.C.

Antigen Agriculture Technology represents a atypical immune-oncology access leveraging the atypical apparatus of activity of Molecular Templates’ ETB technology. ETBs engineered with Antigen Agriculture Technology are able of carrying viral antigens as a burden central the ambition tumor, consistent in the antigens actuality presented on the corpuscle apparent of the bump beef in circuitous with MHC-1. ETB analysis accumulation antigen agriculture are advised to assignment through bifold mechanisms of activity by redirecting a aerial avidity, above-mentioned antigen-specific cytotoxic T corpuscle (CTL) acknowledgment to the bump while at the aforementioned inducing corpuscle afterlife via the enzymatic and abiding abolition of ribosomes. Coupling two audible mechanisms of bump corpuscle killing into one ETB atom provides the abeyant to access ambition penetrance, aggrandize a abiding allowed response, and affected bump resistance.

The poster, blue-blooded “Identification and Functional Profiling of PD-L1 Targeted Engineered Adulteration Bodies for Antigen Agriculture Technology (AST) and Redirection of T corpuscle Acknowledgment to Tumors” summarizes a alternation of preclinical abstracts conducted by Molecular Templates to actualize PD-L1 targeted ETBs that accept antigen agriculture backdrop and to assay the mechanisms by which they can annihilate blight cells.



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“Antigen Agriculture Technology represents a atypical access to immune-oncology that may be alive in patients area accepted immune-oncology approaches accept been exhausted,” said Eric Poma, Ph.D., Molecular Templates’ Chief Executive and Scientific Officer. “We are currently administering in vivo studies with PD-L1 targeted ETBs that accept AST functionality. Our plan is to book an IND and access the dispensary with our aboriginal PD-L1 ETB applicant employing AST in 2019.”

Poster Presentation Details:The affiche (#P9) will be accessible to appearance in Hall E of the Walter E. Johnson Convention Center today, Friday, Nov. 9 from 8 a.m. – 8 p.m. and Saturday, Nov. 10 from 8 a.m. – 8:30 p.m. (all times are E.T.)

The affiche can be begin beneath “Clinical and Scientific Presentations” at http://ir.mtem.com/events-and-presentations/presentations.

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Forward-Looking StatementsThis columnist absolution contains advanced statements for purposes of the Private Securities Litigation Reform Act of 1995 (the “Act”). Molecular disclaims any absorbed or obligation to amend these advanced statements, and claims the aegis of the Act’s Safe Harbor for advanced statements. All statements, added than statements of actual facts, included in this columnist absolution apropos strategy, approaching operations, approaching banking position, approaching revenue, projected expenses, prospects, affairs and objectives of administration are advanced statements. In addition, back or if acclimated in this columnist release, the words “may,” “could,” “should,” “anticipate,” “believe,” “estimate,” “expect,” “intend,” “plan,” “predict” and agnate expressions and their variants, as they chronicle to Molecular, may analyze advanced statements. Examples of such statements include, but are not bound to, statements apropos to Molecular’s expectations with account to its accord with Takeda and its advised use of gain from the offering.

Forward-looking statements are not guarantees of approaching achievement and absorb risks and uncertainties. Actual contest or after-effects may alter materially from those discussed in the advanced statements as a aftereffect of assorted factors including, but not bound to, the uncertainties inherent in the preclinical and analytic development process; whether Molecular’s banknote assets will be acceptable to armamentarium its continuing operations for the periods and/or trials anticipated; the adeptness of Molecular to assure its bookish acreage rights; and legislative, regulatory, political and bread-and-butter developments, as able-bodied as those risks articular beneath the branch “Risk Factors” in Molecular’s filings with the SEC. Any advanced statements independent in this columnist absolution allege alone as of the date hereof, and Molecular accurately disclaims any obligation to amend any advanced statement, whether because of new information, approaching contest or otherwise.

About Molecular Templates Molecular Templates is focused on the discovery, development and commercialization of next-generation immunotoxins alleged Engineered Adulteration Bodies (ETBs) for the analysis of cancers and added austere diseases. For added information, amuse appointment Molecular Templates’ website at www.mtem.com.

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Adam CutlerChief Banking Officeradam.cutler@mtem.com862-204-4006

Source: Molecular Templates, Inc.

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