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The Acceding Will Support the Development of a Abeyant New Analysis Advantage for Assorted Myeloma



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AUSTIN, Texas, Sept. 19, 2018 (GLOBE NEWSWIRE) — Molecular Templates, Inc. (Nasdaq:MTEM) today appear an acceding with Takeda Pharmaceutical Company Bound (Takeda) for the collective development of CD38-targeted engineered adulteration bodies (ETBs) for the analysis of patients with diseases such as assorted myeloma. The advance development applicant is a CD38-targeted ETB that resulted from a antecedent analysis accord amid the two companies.

The parties developed preclinical date ETBs targeting CD38 beneath the above-mentioned analysis collaboration. Takeda and Molecular Templates will added advance the ETBs for the analysis of assorted myeloma beneath this new license, development and commercialization agreement.



“This accord builds on Takeda’s abysmal history and charge to the abstraction of claret cancers, including assorted myeloma,” said Philip Rowlands, Ph.D., Head, Oncology Therapeutic Area Unit at Takeda. “Throughout our analysis accord with Molecular Templates, we accept apparent the affiance of its ETB belvedere for the analysis and development of new therapies. As we aggrandize our accord and abide to analyze next-generation modalities, our achievement is to accompany alternating new and important analysis options for patients.”



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Under the acceding of the agreement, Takeda will accomplish an upfront acquittal of $30 actor and Molecular Templates is acceptable to accept development, authoritative and bartering anniversary payments of up to $632.5 actor if Molecular Templates contest its co-development advantage or $337.5 actor if Molecular Templates does not exercise or opts out of its co-development option. Takeda has additionally agreed to pay royalties on sales of the bartering artefact developed through the collaboration. Molecular Templates and Takeda will allotment appropriately in the development costs.

“We accept formed carefully with Takeda’s accurate aggregation back October 2016 to advance CD38-targeted ETBs with abundant improvements over our own centralized program, MT-4019,” said Eric Poma, Ph.D., Molecular Templates’ Chief Executive and Accurate Officer. “Takeda’s adeptness in assorted myeloma and able antibiotic capabilities accustomed us to advance CD38-targeted ETBs that, of the ones activated to date, are the best almighty ETBs we accept created with our platform.  We attending advanced to affective this affairs into the clinic.”

Multiple myeloma beef broadly accurate the CD38 protein, authoritative it an more important ambition in the development of analysis for assorted myeloma. CD38-targeted ETBs admit the protein and bear a adapted bacterial adulteration that enters the myeloma beef and destroys them through the enzymatic and irreversible abolition of ribosomes. Unlike added CD38-targeted therapies, ETBs are not codicillary on the body’s own allowed arrangement for effectiveness, alms the abeyant of broader and added responses.  

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About Molecular Templates  Molecular Templates is focused on the discovery, development and commercialization of next-generation immunotoxins alleged Engineered Adulteration Bodies (ETBs) for the analysis of cancers and added austere diseases.  For added information, amuse appointment Molecular Templates’ website at www.mtem.com.

Forward-Looking Statements

This columnist absolution contains advanced statements for purposes of the Private Securities Litigation Reform Act of 1995 (the “Act”). Molecular Templates disclaims any absorbed or obligation to amend these advanced statements, and claims the aegis of the Act’s Safe Harbor for advanced statements. All statements, added than statements of actual facts, included in this columnist absolution apropos strategy, approaching results, approaching banking position, approaching revenue, prospects, affairs and objectives of Molecular Templates are advanced statements. In addition, back or if acclimated in this columnist release, the words “may,” “could,” “should,” “anticipate,” “believe,” “estimate,” “expect,” “intend,” “plan,” “predict” and agnate expressions and their variants, as they chronicle to Molecular Templates may analyze advanced statements.  Examples of such statements include, but are not bound to, statements apropos to the development of the abeyant for CD-38 targeting ETBs beneath the agreement; the accepted timing and the abeyant for payments beneath the agreement; and the Company’s acceptance that its proprietary biologic biologic belvedere technology, or ETBs, provides for a differentiated apparatus of activity that may abode some of the limitations associated with currently accessible blight therapeutics.

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Forward-looking statements are not guarantees of approaching achievement and absorb risks and uncertainties. Actual contest or after-effects may alter materially from those discussed in the advanced statements as a aftereffect of assorted factors including, but not bound to, the uncertainties inherent in the preclinical and analytic development process; risks associated with the collective development of CD38-targeted ETBs; whether the Company’s banknote assets will be acceptable to armamentarium its continuing operations for the periods and/or trials anticipated; the adeptness of the Company to assure its bookish acreage rights; and legislative, regulatory, political and bread-and-butter developments, as able-bodied as those risks articular beneath the branch “Risk Factors” in the Company’s filings with the SEC. Any advanced statements independent in this columnist absolution allege alone as of the date hereof, and the Company accurately disclaims any obligation to amend any advanced statement, whether because of new information, approaching contest or otherwise.

Investor Contact:Adam CutlerChief Banking Officeradam.cutler@mtem.com 862-204-4006

Source: Molecular Templates, Inc.

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