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a, Dexamethasone serum contour in accepted mice afterwards a distinct articulate dosage of dexamethasone. Line depicts the fit of first-order biologic abolishment kinetics. n = 4 mice in absolute (of either sex) were acclimated for anniversary time point. Data are provided in Supplementary Table 7. b, Dexamethasone and dexamethasone metabolite levels beyond tissues of antibacterial and C. scindens mono-colonized gnotobiotic mice (GNC. scindens) afterwards 7 h of biologic exposure. Horizontal curve appearance beggarly ethics of n = 6 mice. P ≤ 0.05, P ≤ 0.01, P ≤ 0.001 (unpaired alternate Student’s t-test). Data and P ethics are provided in Supplementary Table 8. c, C. scindens desmolase action for altered corticosteroids. Shaded areas accord to mean ± s.d., n = 6 absolute cultures. d, Bacterial body of animal gut communities. CFU denotes colony-forming units abstinent by anaerobic culturing. Horizontal confined represent beggarly of n = 4 absolute cultures. e, Ex vivo dexamethasone metabolism of gut communities abandoned from 28 humans (each colour represents a animal donor, curve characterize the beggarly of n = 4 carbon assays). C. scindens breed affluence (quantified by species-specific quantitative PCR) is not acceptable to explain the dexamethasone-metabolizing action of these animal gut communities. Data are provided in Supplementary Table 9. f, Alternation amid association CFU ml−1 ethics and dexamethasone (left) or androgen dexamethasone metabolite (right) burning and assembly slopes afterwards 12 h of evolution with anniversary of the 28 human gut communities. P ethics were affected for the absent antecedent that there is aught correlation, adjoin the alternate another that there is non-zero alternation (see Methods).



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