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PARIS and San Diego, California – December 9, 2019 – Sanofi and Synthorx, Inc. (NASDAQ: THOR), a clinical-stage biotechnology aggregation focused on assiduity and convalescent the lives of bodies adversity from blight and autoimmune disorders, entered into a absolute acceding beneath which Sanofi will access all of the outstanding shares of Synthorx for $68 per allotment in cash, which represents an accumulated disinterestedness amount of about $2.5 billion (on a absolutely adulterated basis). The transaction was absolutely accustomed by both the Sanofi and Synthorx Boards of Directors.

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“This accretion fits altogether with our action to anatomy a portfolio of high-quality assets and to advance with innovation, as you will apprehend at our Capital Markets Day tomorrow, December 10. Additionally, it is accumbent with our ambition to anatomy our oncology authorization with potentially practice-changing medicines and atypical combinations,” says Paul Hudson, Chief Executive Officer, Sanofi.

“Synthorx’s awfully atypical assay belvedere has already produced a atom that has the abeyant to become a foundation of the abutting bearing of immuno-oncology accumulated therapies. By selectively accretion the numbers of effector T-cells and accustomed analgesic beef in the body, THOR-707 can be accumulated with our accepted oncology medicines and our arising activity of immuno-modulatory agents for alleviative cancer. Moreover, Synthorx’s activity of engineered lymphokines has abundant affiance not alone for oncology but additionally for acclamation abounding autoimmune and anarchic diseases. ” says John Reed, M.D., Ph.D., Global Head of Assay & Development at Sanofi.

“We are beholden that Sanofi has accustomed the amount of our Expanded Abiogenetic Alphabet belvedere and the abeyant of our activity of optimized assay for blight and autoimmune disorders,” says Laura Shawver, Ph.D., President and Chief Executive Officer, Synthorx. “Importantly, Sanofi has a portfolio of assay that holds absurd affiance for accumulation with our cytokine Synthorins to account patients about the world. I appetite to acknowledge our advisers and the Sanofi alignment for their adamant efforts on account of patients.”

Enhancing Sanofi’s Immuno-Oncology Franchise

Synthorx’s advance immuno-oncology artefact candidate, THOR-707, a alternative of interleukin-2 (IL-2), is in analytic development in assorted solid bump types as a distinct abettor and in accumulated with allowed checkpoint inhibitors. It has the abeyant to become the best-in-class IL-2 ameliorative for the assay of solid tumors and authenticate bigger pharmacology, beneath accepted dosing, and ameliorative ahead back compared to added IL-2 compounds.

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The accession of THOR-707 and Synthorx’s added earlier-stage cytokine programs to Sanofi’s activity will enhance Sanofi’s position in oncology, and in immuno-oncology. We apprehend IL-2 to become a foundation of approaching IO-IO combinations as able-bodied as alms assorted accumulated opportunities with Sanofi’s analytic and pre-clinical oncology assets, including with PD-1, CD-38, and molecules that attune effector T-cells and accustomed analgesic cells.

Synergistic with Sanofi’s absolute platforms

Synthorx’s Expanded Abiogenetic Alphabet belvedere is accepted to be a antecedent for developing a differentiated ameliorative pipeline. Abandoned and in accumulated with added absolute Sanofi platforms, including the Nanobody® technology, it will accredit the aggregation to advance a advanced ambit of atypical biologics, including biologic conjugates, protein fusions, and multi-specific biologics, with applications above oncology and extending to added ameliorative areas.

Transaction Acceding

Under the acceding of the alliance agreement, Sanofi will arise a banknote breakable action to access all of the outstanding shares of Synthorx accepted banal for $68 per allotment in banknote for a absolute action amount of about $2.35 billion. The $68 per allotment accretion amount represents a 172% exceptional to Synthorx’s closing amount on December 6, 2019.

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The cleanup of the breakable action is accountable to accepted closing conditions, including the breakable of at atomic a majority of the outstanding shares of Synthorx accepted stock, the cessation or abortion of the cat-and-mouse aeon beneath the Hart-Scott-Rodino Antitrust Improvements Act of 1976, and added accepted conditions. Afterward the acknowledged achievement of the breakable offer, a wholly endemic accessory of Sanofi will absorb with Synthorx and the outstanding Synthorx shares not tendered in the breakable action will be adapted into the appropriate to accept the aforementioned $68 per allotment in banknote paid in the breakable offer. The breakable action is accepted to arise in December 2019. Sanofi affairs to accounts the transaction with banknote on hand. Accountable to the achievement or abandonment of accepted closing conditions, Sanofi expects to complete the accretion in the aboriginal division of 2020.

Morgan Stanley & Co. is acting as banking adviser to Sanofi and Weil, Gotshal & Manges LLP is acting as its acknowledged counsel. Centerview Partners LLC is acting as absolute banking adviser to Synthorx and Cooley LLP is acting as its acknowledged counsel.

About SynthorxSynthorx, Inc. is a clinical-stage biotechnology aggregation focused on assiduity and convalescent the lives of bodies with blight and autoimmune disorders. Synthorx’s proprietary, first-of-its-kind Expanded Abiogenetic Alphabet belvedere technology expands the abiogenetic cipher by abacus a new DNA abject brace and is advised to actualize optimized biologics, referred to as Synthorins. A Synthorin is a protein optimized through assimilation of atypical amino acids encoded by the new DNA abject brace that enables site-specific modifications, which enhance the pharmacological backdrop of these therapeutics. The company’s advance immuno-oncology (IO) artefact candidate, THOR-707, a alternative of IL-2, is in development in assorted bump types as a distinct abettor and in accumulated with an allowed checkpoint inhibitor. The aggregation was founded based on important discoveries by Dr. Floyd Romesberg and The Scripps Assay Institute. Synthorx is headquartered in La Jolla, Calif. For added information, visit www.Synthorx.com. 

Sanofi and Synthorx Forward-Looking StatementsThis advice contains advanced statements. Advanced statements are statements that are not absolute facts and may accommodate projections and estimates and their basal assumptions, statements apropos plans, objectives, intentions and expectations with account to approaching banking results, events, operations, services, artefact development and potential, and statements apropos approaching performance. Advanced statements are about articular by the words “expects”, “anticipates”, “believes”, “intends”, “estimates”, “plans”, “will be” and agnate expressions. Although Sanofi’s and Synthorx’s administration anniversary believes that the expectations reflected in such advanced statements are reasonable, investors are cautioned that advanced advice and statements are accountable to assorted risks and uncertainties, abounding of which are difficult to adumbrate and about above the ascendancy of Sanofi and Synthorx, that could account absolute after-effects and developments to alter materially from those bidding in, or adumbrated or projected by, the advanced advice and statements. These risks and uncertainties accommodate amid added things, risks accompanying to Sanofi’s and Synthorx’s adeptness to complete the accretion on the proposed acceding or on the proposed timeline, including the cancellation of appropriate authoritative approvals, the achievability that aggressive offers will be made, added risks associated with active business accumulated transactions, such as the accident that the businesses will not be chip successfully, that such affiliation may be added difficult, time-consuming or cher than accepted or that the accepted allowances of the accretion will not be realized, risks accompanying to approaching opportunities and affairs for the accumulated company, including ambiguity of the accepted banking achievement and after-effects of the accumulated aggregation afterward achievement of the proposed acquisition, disruption from the proposed accretion authoritative it added difficult to conduct business as accepted or to advance relationships with customers, employees, manufacturers, suppliers or accommodating groups, and the achievability that, if the accumulated aggregation does not accomplish the perceived allowances of the proposed accretion as rapidly or to the admeasurement advancing by banking analysts or investors, the bazaar amount of Sanofi’s shares could decline, as able-bodied as added risks accompanying Sanofi’s and Synthorx’s corresponding businesses, including the adeptness to abound sales and revenues from absolute articles and to develop, commercialize or bazaar new products, competition, including abeyant all-encompassing competition, the uncertainties inherent in assay and development, including approaching analytic abstracts and analysis, authoritative obligations and blank by authoritative authorities, such as the FDA or the EMA, including decisions of such authorities apropos whether and back to accept any drug, accessory or biological appliance that may be filed for any artefact candidates as able-bodied as decisions apropos labelling and added affairs that could affect the availability or bartering abeyant of any artefact candidates, the absence of a agreement that any artefact candidates, if approved, will be commercially successful, risks associated with bookish property, including the adeptness to assure bookish acreage and avert patents, approaching litigation, the approaching approval and bartering success of ameliorative alternatives, and airy bread-and-butter conditions. While the account of factors presented actuality is representative, no account should be advised a account of all abeyant risks, uncertainties or assumptions that could accept a actual adverse aftereffect on companies’ circumscribed banking action or after-effects of operations. The above factors should be apprehend in affiliation with the risks and cautionary statements discussed or articular in the accessible filings with the U.S. Balance and Exchange Commission (the “SEC”) and the AMF fabricated by Sanofi, including those listed beneath “Risk Factors” and “Cautionary Account Apropos Forward-Looking Statements” in Sanofi’s anniversary address on Form 20-F for the year concluded December 31, 2018, and the accepted letters on Form 8-K, anniversary letters on Form 10-Q and anniversary letters on Form 10-K filed by Synthorx with the SEC. The advanced statements allege alone as of the date hereof and, added than as appropriate by applicative law, Sanofi and Synthorx do not undertake any obligation to amend or alter any advanced advice or statements

 

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Additional Advice for US shareholders

The breakable action for the outstanding shares of Synthorx accepted banal referenced in this columnist absolution has not yet commenced. This columnist absolution is for advisory purposes alone and is neither an action to acquirement nor a address of an action to advertise securities, nor is it a acting for the breakable action abstracts that Sanofi and its accretion accessory will book with the SEC, aloft the admission of the breakable offer. At the time the breakable action is commenced, Sanofi and its accretion accessory will book a breakable action account on Schedule TO and thereafter Synthorx will book a Solicitation/Recommendation Account on Schedule 14D-9 with the SEC with account to the breakable offer. THE TENDER OFFER MATERIALS (INCLUDING AN OFFER TO PURCHASE, A RELATED LETTER OF TRANSMITTAL AND CERTAIN OTHER TENDER OFFER DOCUMENTS) AND THE SOLICITATION/RECOMMENDATION STATEMENT ON SCHEDULE 14D-9 WILL CONTAIN IMPORTANT INFORMATION. SYNTHORX STOCKHOLDERS ARE URGED TO READ THESE DOCUMENTS CAREFULLY WHEN THEY BECOME AVAILABLE (AS EACH MAY BE AMENDED OR SUPPLEMENTED FROM TIME TO TIME) BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION THAT HOLDERS OF SYNTHORX SECURITIES SHOULD CONSIDER BEFORE MAKING ANY DECISION REGARDING TENDERING THEIR SECURITIES. The Action to Purchase, the accompanying Letter of Transmittal and assertive added breakable action documents, as able-bodied as the Solicitation/Recommendation Statement, will be fabricated accessible to all holders of Synthorx banal at no amount to them. The breakable action abstracts and the Solicitation/Recommendation Account will be fabricated accessible for chargeless at the SEC’s website at www.sec.gov. Additional copies may be acquired for chargeless by contacting Sanofi or Synthorx. Copies of the abstracts filed with the SEC by Synthorx will be accessible chargeless of allegation on Synthorx’s internet website at https://ir.synthorx.com or by contacting Synthorx’s Investor Relations Department at [email protected] Copies of the abstracts filed with the SEC by Sanofi will be accessible chargeless of allegation on Sanofi’s internet website at https://en.sanofi.com/investors or by contacting Sanofi’s Investor Relations Department at [email protected]

 

In accession to the Action to Purchase, the accompanying Letter of Transmittal and assertive added breakable action documents, as able-bodied as the Solicitation/Recommendation Statement, Sanofi files anniversary and appropriate letters and added advice with the SEC and Synthorx files annual, anniversary and appropriate letters and added advice with the SEC. You may apprehend and archetype any letters or added advice filed by Sanofi and Synthorx at the SEC accessible advertence allowance at 100 F. Street, N.E., Washington D.C. 20549. Please alarm the Commission at 1-800-SEC-0330 for added advice on the accessible advertence room. Sanofi’s and Synthorx’s filings with the SEC are additionally accessible to the accessible from bartering document-retrieval casework and at the website maintained by the SEC at www.sec.gov

 

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